
- Home
- Skincare
- Skincare Systems
- Anti Aging
- Anti-Aging System



This Is
Great For
- People looking to prevent signs of aging
- Adult Men and Women of all ages
- Improving skin elasticity and youthfulness
- Anyone seeking to reverse the signs of aging
- Correcting damaged caused by the sun
- Reducing fine lines and wrinkles
- Post laser and peel procedure treatments
- Decreasing blemishes and acne
- Evening skin tone and reducing discoloration
- Increase hydration levels in the skin
Overview
Product Overview:
Ingredients: Per Product In This System
Suggested Usage: Per Product In This System
As a precaution, retinol cream products should not be used by pregnant women or women who intend to become pregnant in the near future. Though there are no reports of topical retinol having any negative effect on fetal development, some problems have been reported with ingested retinoic acid.
Retinol is prone to increased photosensitivity. Always use a high, broad spectrum sunscreen when using this product.





















Apply evenly over face and neck avoiding eye area. Allow to absorb before applying additional products. Can be used twice daily or as directed by a physician. Do not rinse. Tighten cap on jar after use to prevent pads from drying out.
As an Acne Treatment: Can be used twice daily.
As an Anti-Aging Treatment: Can be used two to four times per week.
When using this product avoid contact with eyes. If contact occurs, flush thoroughly with water.
Stop use and ask doctor if rash or irritation develops and lasts.
Alpha and beta hydroxy acids are photosensitizing. A broad-spectrum sun protection is a must when hydroxy acids are part of your skin care regimen.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.





How It Works: Per Product In This System
Retinol is a form of vitamin A. In research, it is recognized for its effects on cellular growth, photoaging, and acne. Topical retinol reduces the appearance of fine lines and wrinkles while improving skin tone and elasticity. This formula contains a .25% retinol concentration, providing a clinically effective dose ideal for protecting the skin against general signs of aging and sun damage.
One of the ways retinol works is by increasing glycosaminoglycan expression and procollagen I immunostaining. Increasing glycosaminoglycan expression promotes water retention in the skin, at the cellular level, for optimized skin hydration. Increased collagen promotes the elimination of fine lines and wrinkles. By increasing skin matrix synthesis, retinol-treated skin has a greater defense against injury and age with an overall improvement in skin appearance.
Long-term exposure to the sun’s ultraviolet irradiation damages skin collagen and elastin (extracellular matrix), resulting in the wrinkled appearance of sun-exposed skin and premature skin aging. Skin keratinocytes are reported to metabolize retinol to retinoic acid, suggesting that retinol may also be helpful in improving skin photodamage. Clinical research supports the benefits of topical retinol to safely and effectively improve the appearance of photoaged skin with observed increases in collagen and skin matrix integrity. [4]
Vitamin C is a naturally occurring antioxidant that our bodies cannot produce on its own. Bioavailability of vitamin C in the skin is inadequate when it is administered orally (e.g. supplement or diet). The use of topical ascorbic acid, the chemically active and natural form of vitamin C, is well recognized in dermatological practices. Vitamin C is important for the maintenance of healthy skin because of its role as a water-soluble free radical scavenger and an essential cofactor for collagen synthesis. Vitamin C protects the skin from oxidative stress, such as UV rays, by donating electrons to neutralize the free radicals.
Vitamin C contains anti-inflammatory properties, making it an effective treatment in skin conditions like acne vulgaris and rosacea. Vitamin C in topical formulations tends to be ineffective in delivery and break down, resulting in a brownish discoloration. Sodium ascorbyl phosphate, however, is a stable precursor of vitamin C that ensures a constant delivery of vitamin C into the skin. The potent antimicrobial effects of sodium ascorbyl phosphate have warranted its role in treating and preventing acne.
Coenzyme Q10, also known as ubiquinone, is an antioxidant vital for cellular energy production. WIth age and external stress factors in human skin (e.g. UV ray exposure), endogenous levels of COQ10 start to decline. Research has shown that energy metabolism shifts to a predominantly non-mitochondrial pathway, deeming it functionally anaerobic with advancing age. CoQ10 positively influences the age-affected cellular metabolism and works at the cellular level to combat signs of aging. Topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin. [7] Topical CoQ10 works deep into the layers of the skin with antioxidant and anti-inflammatory properties to reduce wrinkle depth, increase the integrity of skin collagen, and prevent premature aging caused by sun exposure.
Squalene is a polyunsaturated that occurs naturally in fish oils and vegetable oils. Squalene is one of the most common lipids produced by human skin cells. Human sebum contains 13% squalene as one of its major constituents. Squalene is recognized in research for its antioxidant, detoxification, skin hydrating, and emollient (skin softening) effects. The natural production of squalene in the body slows significantly after the age thirty, contributing to dry skin, and warranting its topical application to the skin for hydration.
Bisabolol, (-)-α-bisabolol, is commonly used as a soothing ingredient in cosmetics. Bisabolol has been recognized in research for its anti-inflammatory properties that may extend to treating and preventing skin irritation.
Allantoin is commonly used in moisturizers as a humectant offering superior hydration for dry skin. Literature has also demonstrated anti-irritant properties of allantoin.
Long term topical application of retinol has shown to significantly increase glycosaminoglycan expression and procollagen I immunostaining while significantly improving the appearance of fine wrinkles associated with aging. [1]
Research has shown retinol to safely and effectively treat and improve the appearance of photoaged skin. Eight weeks of retinol-infused moisturizer application significantly reduced fine lines, wrinkles, pigmentation, and photodamage with significant increases in skin elasticity and firmness. These improvements were significant at week 4 and continued to improve progressively until the eighth week. [2] Retinol has also shown to inhibit damage incurred from prolonged ultraviolet (UV) light exposure while stimulating collagen synthesis in photoaged skin. [3] Additional studies support the long-term and consistent use of retinol as an effective anti-aging molecule that can treat and improve the signs of aging associated with excessive sun exposure. [4]
Research has shown sodium ascorbyl phosphate to have a strong antimicrobial effect. Long term application of sodium ascorbyl phosphate has shown to safely and effectively treat and prevent acne vulgaris when administered alone and with other ingredients. The efficacy of sodium ascorbyl phosphate ranked as excellent at 76.9%, which is a superior rating compared to widely prescribed acne treatments. [5] Dermatological research has deemed vitamin C to have a optimal safety profile and an effective means of treating photoaging, hyperpigmentation, and tissue inflammation while promoting tissue healing. [6]
Studies have shown the antioxidant properties of topical CoQ10 to penetrate layers of the epidermis to reduce wrinkle depth and prevent signs of photoaging. CoQ10 has shown to protect the skin against UV-induced oxidative stress and the expression of collagenase. Inhibition of collagenase prevents the degradation of collagen and promotes the integrity of collagen in the skin. [8] [9]
Additional research has demonstrated the anti-inflammatory properties of CoQ10 to suppress inflammatory responses in the skin (e.g. UV radiation exposure) further preventing premature aging caused by sun exposure. [10]
A commonly used ingredient to promote skin hydration, research has demonstrated squalene to exhibit antioxidant activity in the skin while protecting the human skin surface from oxidative stress caused by UV exposure. [11] Research has shown squalene to moisturize the skin with high skin tolerability and with a low potential for irritation. [12]
At the cellular level, bisabolol has demonstrated downregulation of the gene expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These findings represent the anti-inflammatory effects of bisabolol that may extend to the protection and treatment against photodamage and acne. [13] Consistent application of bisabolol for eight weeks resulted in significant a lightening effect in subjects with pigmented skin. [14]
Allantoin is commonly used in moisturizers as a humectant, offering hydration for dry skin. In addition to promoting skin hydration, allantoin is also recognized for treating skin irritation. [15] [16]
- 1. Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S. (2007). Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 143(5):606-12.
- 2. Tucker-Samaras S, Zedayko T, Cole C, Miller D, Wallo W, Leyden JJ. (2009). A stabilized 0.1% retinol facial moisturizer improves the appearance of photodamaged skin in an eight-week, double-blind, vehicle-controlled study. J Drugs Dermatol. 8(10):932-6.
- 3. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ. (1996). Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 379(6563):335-9.
- 4. Randhawa M, Rossetti D, Leyden JJ, Fantasia J, Zeichner J, Cula GO, Southall M, Tucker-Samaras S. (2015). One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial. J Drugs Dermatol. 14(3):271-80.
- 5. Klock J, Ikeno H, Ohmori K, Nishikawa T, Vollhardt J, Schehlmann V. (2005). Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci. 27(3):171-6.
- 6. Telang PS. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal. 4(2):143-146.
- 7. Prahl S, Kueper T, Biernoth T, Wöhrmann Y, Münster A, Fürstenau M, Schmidt M, Schulze C, Wittern KP, Wenck H, Muhr GM, Blatt T. (2008). Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care. Biofactors. 32(1-4):245-55.
- 8. Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D, Sauermann G, Schreiner V, Stäb F, Steckel F. (1999). Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 9(2-4):371-8.
- 9. Knott A, Achterberg V, Smuda C, Mielke H, Sperling G, Dunckelmann K, Vogelsang A, Krüger A, Schwengler H, Behtash M, Kristof S, Diekmann H, Eisenberg T, Berroth A, Hildebrand J, Siegner R, Winnefeld M, Teuber F, Fey S, Möbius J, Retzer D, Burkhardt T, Lüttke J, Blatt T. (2015). Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. Biofactors. 41(6):383-90. doi: 10.1002/biof.1239. Epub 2015 Dec 9.
- 10. Fuller B, Smith D, Howerton A, Kern D. (2006). Anti-inflammatory effects of CoQ10 and colorless carotenoids. J Cosmet Dermatol. 5(1):30-8.
- 11. Kelly GS. (1999). Squalene and its potential clinical uses. Altern Med Rev. 4(1):29-36.
- 12. Kato S, et al. Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. Basic Clin Pharmacol Toxicol. 2009;104(6):483–487.
- 13. Kim S, Jung E, Kim JH, Park YH, Lee J, Park D. (2011). Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. Food Chem Toxicol. 49(10):2580-5.
- 14. Lee J, Jun H, Jung E, Ha J, Park D. (2010). Whitening effect of alpha-bisabolol in Asian women subjects. Int J Cosmet Sci. 32(4):299-303.
- 15. Savić VLj, Nikolić VD, Arsić IA, Stanojević LP, Najman SJ, Stojanović S, Mladenović-Ranisavljević II. (2015). Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root. Phytother Res. 29(8):1117-22.
- 16. Rodan, K., Fields, K., Majewski, G., & Falla, T. (2016). Skincare Bootcamp: The Evolving Role of Skincare. Plastic and Reconstructive Surgery Global Open. 4(12 Suppl), e1152.
- 17. Farris PK. Cosmetical Vitamins: Vitamin C. In: Draelos ZD, Dover JS, Alam M, editors. Cosmeceuticals. Procedures in Cosmetic Dermatology. 2nd ed. New York: Saunders Elsevier; 2009. pp. 51–6.
- 18. Ho ET, Trookman NS, Sperber BR, Rizer RL, Spindler R, Sonti S, Gotz V, Mehta R. (2012). A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. J Drugs Dermatol. 11(1):64-9.
Vitamin C is a naturally occurring antioxidant that our bodies cannot produce on its own. Bioavailability of vitamin C in the skin is inadequate when it is administered orally (e.g. supplement or diet). Vitamin C is important for the maintenance of healthy skin because of its role as a water-soluble free radical scavenger and an essential cofactor for collagen synthesis.Vitamin C protects the skin from oxidative stress, such as UV rays, by donating electrons to neutralize the free radicals.
Long term vitamin C application has shown to significantly increase the production of facial collagen. Vitamin C contains anti-inflammatory properties, making it an effective treatment in skin conditions like acne vulgaris and rosacea with benefit to skin complexion.
iCorrect Vita-C Brightening contains five different forms of vitamin for optimal delivery and action. This includes sodium ascorbyl phosphate and magnesium ascorbyl phosphate, stable precursors of vitamin C that ensure a constant delivery of vitamin C and its antioxidant effects into the skin. Another form of vitamin C in this formula, tetrahexyldecyl ascorbate, has shown to improve skin hydration and promote collagen formation with clinically visible and statistically significant improvements in facial wrinkles. Ascorbyl glucoside has demonstrated reduction in facial hyperpigmentation spots while topical ascorbyl palmitate effectively reduces free radical formation and enhances the absorption of vitamin C into the skin.
Vitamin E provides protection against UV-induced skin damage through a combination of antioxidant and UV absorptive properties. A major lipid soluble antioxidant naturally occurring in skin, vitamin E is also acknowledged for its wound healing and skin repair properties that can improve the cosmetic outcomes of sun damage. Vitamin E also contains anti-inflammatory properties and, like vitamin C, topical application has shown effectiveness in the treatment of inflammatory dermatoses, acne, and pigmentation disorders. Following topical application, vitamin E contributes to antioxidant defenses as it circulates in the cell membranes and extracellular lipid matrix of the stratum corneum (outer layer of the skin). Topical alpha-tocopherol (vitamin E) is resistant to oxidation (breakdown) for optimal bioavailability and skin layer penetration.
Reactive oxygen species can negatively impact the biosynthesis of collagen and glycosaminoglycans in skin. Vitamin E can combat the oxidative stress to protect collagen and glycosaminoglycan levels. The combination of vitamin C with vitamin E results in synergy, particularly with UV protection. Vitamin C regenerates oxidized vitamin E and both inhibit acute UV damage from sunburn and tanning as well as chronic exposure to UV radiation associated with sun-induced skin aging and skin cancer.
Allantoin is commonly used in moisturizers as a humectant offering superior hydration for dry skin. Literature has also demonstrated anti-irritant properties of allantoin.
Bisabolol, (-)-α-bisabolol, is an important phytochemical in chamomile that contributes to its soothing and anti-inflammatory properties that may extend to treating and preventing skin irritation.
Dermatological research has deemed vitamin C to have an optimal safety profile and an effective means of treating photoaging, hyperpigmentation, and tissue inflammation while promoting tissue healing. [1] One study found three months of topical vitamin C to significantly improve photodamaged facial skin 84.2% better than control. Subjects demonstrated statistically significant improvements in fine lines and coarse wrinkles, tactile roughness, skin laxity/tone, skin yellowing, and overall features. [2]
Additional research has shown twelve weeks of topical vitamin C, including tetrahexyldecyl ascorbate, to improve skin hydration and promote collagen formation with clinically visible and statistically significant improvements in facial wrinkles. Improved skin hydration was reflected by decreased photoaged scores of the cheeks, peri-oral area, and peri-orbital area. [3]
Research has shown sodium ascorbyl phosphate to have a strong antimicrobial effect. Long term application of sodium ascorbyl phosphate has shown to safely and effectively treat and prevent acne vulgaris when administered alone and with other ingredients. The efficacy of sodium ascorbyl phosphate ranked as excellent at 76.9%, which is a superior rating compared to widely prescribed acne treatments. [4]
Ascorbyl glucoside has demonstrated contributory effects on the reduction of facial hyperpigmentation spots as a primary skin-lightening agent. [5] Additional research has demonstrated ascorbyl glucoside to treat melasma and postinflammatory hyperpigmentation. [6]
One study found ascorbyl palmitate was able to cross biological barriers and satisfied the tissue demand for ascorbate compared to ascorbic acid alone. This suggests a greater delivery of vitamin C into the tissues when accompanied by ascorbyl palmitate for greater bioactivity. [7] Research has also observed topical ascorbyl palmitate to effectively decrease the level of formation of free radicals. [8]
Research has illustrated the anti-inflammatory and antioxidant properties of vitamin E and, like vitamin C, its topical application has shown effectiveness in the treatment of inflammatory dermatoses, acne, pigmentation disorders, wound healing. [9] Reactive oxygen species can negatively impact the biosynthesis of collagen and glycosaminoglycans in skin. Vitamin E can combat the oxidative stress to protect collagen and glycosaminoglycan levels for anti-aging benefit. [10]
Research has demonstrated the synergy of vitamins C and E to protect the skin from UV radiation as vitamin C regenerates oxidized vitamin E and both inhibit acute UV damage of sunburn and tanning as well as chronic UV photoaging and skin cancer. [11]
Research has shown 1% of alpha-tocopherol, in combination with vitamin C, enhances the skin’s UV protection. The combination of these two low molecular weight antioxidants provides a synergistic protection against oxidative stress in skin, optimizing protection against sun-induced aging and skin cancer. [12] Additional studies have demonstrated the effective synergy of vitamin C with vitamin E to provide noteworthy protection from oxidative stress associated with sun damage and UV radiation. [13][14][15][16]
Allantoin is commonly used in moisturizers as a humectant, offering hydration for dry skin. In addition to promoting skin hydration, allantoin is also recognized for treating skin irritation. [17][18]
At the cellular level, bisabolol has demonstrated downregulation of the gene expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These findings represent the anti-inflammatory effects of bisabolol that may extend to the protection and treatment against photodamage and acne. [19] Consistent application of bisabolol for eight weeks resulted in significant a lightening effect in subjects with pigmented skin. [20]
- 1. Telang PS. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal. 4(2):143-146.
- 2. Traikovich SS. (1999). Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg. 125(10):1091-8.
- 3. Fitzpatrick RE, Rostan EF. (2002). Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 28(3):231-6.
- 4. Klock J, Ikeno H, Ohmori K, Nishikawa T, Vollhardt J, Schehlmann V. (2005). Sodium ascorbyl phosphate shows in vitro and in vivo efficacy in the prevention and treatment of acne vulgaris. Int J Cosmet Sci. 27(3):171-6.
- 5. Hakozaki T, Takiwaki H, Miyamoto K, Sato Y, Arase S. (2006) Ultrasound enhanced skin-lightening effect of vitamin C and niacinamide. Skin Res. Technol. 12:105–113.
- 6. Taylor MB, Yanaki JS, Draper DO, Shurtz JC, Coglianese M. (2013). Successful short-term and long-term treatment of melasma and postinflammatory hyperpigmentation using vitamin C with a full-face iontophoresis mask and a mandelic/malic acid skin care regimen. J Drugs Dermatol. 12(1):45-50.
- 7. Pokorski M, Marczak M, Dymecka A, Suchocki P. (2003). Ascorbyl palmitate as a carrier of ascorbate into neural tissues. J Biomed Sci. 10(2):193-8.
- 8. Jurkovic P, Sentjurc M, Gasperlin M, Kristl J, Pecar S. (2003). Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions. Eur J Pharm Biopharm. 56(1):59-66.
- 9. Burke KE. (2007). Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther. 20(5):314-21.
- 10. Tanaka H, Okada T, Konishi H, Tsuji T. (1993). The effects of reactive oxygen species on the biosynthesis of collagen and glycosaminoglycans in cultured human dermal fibroblasts. Arch Dermatol Res. 285:352–5.
- 11. Burke KE. (2007). Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther. 20(5):314-21.
- 12. Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA, et al. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. J Invest Dermatol. 125:826–32.
- 13. Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR. (2008). A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. J Am Acad Dermatol. 59(3):418-25.
- 14 Wu Y, Zheng X, Xu XG, Li YH, Wang B, Gao XH, Chen HD, Yatskayer M, Oresajo C. (2013). Protective effects of a topical antioxidant complex containing vitamins C and E and ferulic acid against ultraviolet irradiation-induced photodamage in Chinese women. J Drugs Dermatol. 12(4):464-8.
- 15. Oresajo C, Stephens T, Hino PD, Law RM, Yatskayer M, Foltis P, Pillai S, Pinnell SR. (2008). Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. J Cosmet Dermatol. 7(4):290-7.
- 16. Sorg O, Tran C, Saurat JH. (2001). Cutaneous vitamins A and E in the context of ultraviolet- or chemically-induced oxidative stress. Skin Pharmacol Appl Skin Physiol. 14(6):363-72.
- 17. Savić VLj, Nikolić VD, Arsić IA, Stanojević LP, Najman SJ, Stojanović S, Mladenović-Ranisavljević II. (2015). Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root. Phytother Res. 29(8):1117-22.
- 18. Rodan, K., Fields, K., Majewski, G., & Falla, T. (2016). Skincare Bootcamp: The Evolving Role of Skincare. Plastic and Reconstructive Surgery Global Open. 4(12 Suppl), e1152.
- 19. Kim S, Jung E, Kim JH, Park YH, Lee J, Park D. (2011). Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. Food Chem Toxicol. 49(10):2580-5.
- 20. Lee J, Jun H, Jung E, Ha J, Park D. (2010). Whitening effect of alpha-bisabolol in Asian women subjects. Int J Cosmet Sci. 32(4):299-303.
Hyaluronic acid (HA) is a glycosaminoglycan with a unique capacity to bind and retain water molecules. A number of studies have demonstrated the important role hyaluronic acid plays in protecting cells from UV radiation. Hyaluronic acid is produced mainly by fibroblasts and keratinocytes in the skin. It is a key molecule that is naturally occurring and highly conserved as a polysaccharide in the skin’s tissue as it plays an important role in stratum corneum hydration. Due to its considerable capacity to bind water, hyaluronic acid has greater skin hydration properties than other polysaccharides.
One study demonstrated topical hyaluronic acid to significantly improve periocular wrinkle depth and skin roughness. Skin hydration and elasticity were also significantly improved by topical hyaluronic acid. [4]
The soybean, also known as the soya bean, is a species of legume native to east Asia. It contains a number of bioactive compounds, including phenolic acids, flavonoids, proteins, and isoflavonoids (e.g. quercetin and genistein). Dermatological research has recognized the anti-inflammatory, collagen-stimulating, anti-aging, antioxidant, skin lightening, and UV radiation protective properties of soybean.
Elastic fibres are essential extracellular matrix components of the skin. They contribute to skin resilience and elasticity. As the skin ages, elastin production is reduced and elastase activity is accelerated. Elastase is an enzyme that breaks down elastin, resulting in skin sagging and reduced skin elasticity. Soybean extracts can promote elastin production while inhibiting elastase activity. This protects elastic fibres for youthful skin appearance and optimal integrity. One study found the topical application of soy extract to result in a 9.46% increase in the thickness of the epidermis (outer layers of the skin). [7]
Research supports the anti-aging effects of soybean, demonstrating increases in skin cell collagen and hyaluronic acid production with the capacity to rejuvenate the structure of aging skin. The antioxidant properties of soybean contribute to its skin whitening effects by inhibiting tyrosinase, an enzyme associated with skin pigmentation.
Green tea is rich in naturally occurring polyphenols that exhibit significant antioxidant activity with potent protective benefits on the immune system and the skin. The majority of green tea polyphenols are flavanols and catechins. Of the four main catechins in green tea, epigallocatechin-3-gallate (EGCG) is the most abundant and extensively studied catechin with potent therapeutic effects in skin. Topical green tea polyphenols have demonstrated protective effects from the negative effects of UV radiation on skin (e.g. redness, irritation, sunburn, and DNA damage). This, in turn, prevents premature aging of the skin. Research has also shown topical green tea extract to reduce crow’s feet wrinkles by up to 36.3% and promote up to a 49.99% improvement in skin smoothness. [12][13]
Aloe barbadensis, also referred to as aloe vera, is recognized in research for its potent antibacterial and antioxidant properties. Aloe contains small molecular weight immunomodulators that restore cellular function following UV-B radiation exposure. Research has demonstrated the anti-inflammatory properties of topical aloe to effectively treat inflammatory skin conditions such as UV-induced inflammation, redness, and irritation within two days of use. [5] Aloe vera is also a natural humectant that effectively moisturizes skin to treat and prevent dry skin.
Research has shown topical application of hyaluronic acid to safely and effectively improve the health and appearance skin affected by inflammatory conditions. [1] Increased TEWL impairs enzymatic functions required for normal desquamation of the skin and results in the visible appearance of dry, flaky skin. Panthenol works synergistically with hyaluronic acid as both ingredients reduce TEWL. Research has demonstrated the humectant properties of the topical application of hyaluronic acid by increasing the hydration of the strata corneum. [2] Additional research has demonstrated the capacity of hyaluronic acid to reduce acne scars. [3]
Utilizing female subjects (age 30-60) with periocular wrinkles, one study demonstrated topical hyaluronic acid to significantly improve wrinkle depth and skin roughness. Skin hydration and elasticity were also significantly improved by topical hyaluronic acid. [4]
In vitro research has observed soybean extract to promote elastin activity, inhibit elastase activity, and protect elastic fibres from degradation. [5] Additional research has shown soybean extract to provide anti-aging effects, including wrinkle reduction, similar to that of retinoids, however, with added photoprotective effects from the sun and UV radiation. [6]
Long-term (6 months) topical application of soy extract resulted in a 9.46% increase in the thickness of the epidermis with a significant increases in collagen and elastic fibers. [7] Additional research has observed soybean extract to increase collagen and hyaluronic acid production in skin cells with an increased number of dermal papillae. [8] Literature supports the antioxidant properties of soybeans and its inhibitory effects on tyrosinase, resulting in skin whitening. [9]
Studies have shown topical application of green tea extract on skin exposed to UV radiation to inhibit erythema (e.g. redness, irritation), reduce the number of cells with sunburn, and reduce DNA damage. [10][11] Research has observed eight weeks of topical green tea extract to reduce crow’s feet wrinkles by up to 36.3% as attributed by the antioxidant activity of its polyphenols. [12] Additional research has shown topical green tea to contribute to a 49.99% improvement in skin smoothness while improving facial wrinkles. [13]
Research has shown topical two days of aloe vera application to effectively treat UV-induced erythema to a greater extent than 1% hydrocortisone. [14] Additional research has shown aloe to contain natural humectant properties and improve skin moisture in dry skin. [15]
- 1. Schlesinger T, Rowland Powell C. (2014). Efficacy and Safety of a Low Molecular Weight Hyaluronic Acid Topical Gel in the Treatment of Facial Seborrheic Dermatitis Final Report. The Journal of Clinical and Aesthetic Dermatology. 7(5):15-18.
- 2. Verdier-Sévrain S, Bonté F. (2007). Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 6(2):75-82.
- 3. Halachmi S, Ben Amitai D, Lapidoth M. (2013). Treatment of acne scars with hyaluronic acid: an improved approach. J Drugs Dermatol. 12(7):e121-3.
- 4. Pavicic T, Gauglitz GG, Lersch P, Schwach-Abdellaoui K, Malle B, Korting HC, Farwick M. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol. 10(9):990-1000.
- 5. Zhao R, Bruning E, Rossetti D, Starcher B, Seiberg M, Iotsova-Stone V. (2009). Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity. Exp Dermatol. 18(10):883-6.
- 6. Park NH, Park JS, Kang YG, Bae JH, Lee HK, Yeom MH, Cho JC, Na YJ. (2013). Soybean extract showed modulation of retinoic acid-related gene expression of skin and photo-protective effects in keratinocytes. Int J Cosmet Sci. 35(2):136-42.
- 7. Accorsi-Neto A, Haidar M, Simões R, Simões M, Soares-Jr J, Baracat E. (2009). Effects of Isoflavones on the Skin of Postmenopausal Women: A Pilot Study. Clinics (Sao Paulo, Brazil). 64(6):505-510.
- 8. Südel KM, Venzke K, Mielke H, Breitenbach U, Mundt C, Jaspers S, Koop U, Sauermann K, Knussman-Hartig E, Moll I, Gercken G, Young AR, Stäb F, Wenck H, Gallinat S. (2005). Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochem Photobiol. 81(3):581-7.
- 9. Chae GY, Ha BJ. (2011). The comparative evaluation of fermented and non-fermented soybean extract on antioxidation and whitening. Toxicological Research. 27(4):205-209.
- 10. Elmets CA, Singh D, Tubesing K, Matsui M, Katiyar S, Mukhtar H. (2001). Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. Journal of the American Academy of Dermatology. 44(3):425–432.
- 11. Camouse MM, Domingo DS, Swain FR, et al. (2009). Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin. Experimental Dermatology. 18(6):522–526.
- 12. Hong YH, Jung EY, Shin KS, Yu KW, Chang UJ, Suh HJ. (2013). Tannase-converted green tea catechins and their anti-wrinkle activity in humans. J Cosmet Dermatol. 12(2):137-43.
- 13. Mahmood T, Akhtar N. (2013). Combined topical application of lotus and green tea improves facial skin surface parameters. Rejuvenation Res. 16(2):91-7.
- 14. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. (2014). Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat. 25(2):123-9.
- 15. Dal'Belo SE, Gaspar LR, Maia Campos PM. (2006). Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Skin Res Technol. 12(4):241-6.
Salicylic acid, in combination with lactic acid, has been administered to treat and reverse the negative effects of sun damage. One study demonstrated a significant reduction in fine lines, wrinkles, and skin dryness after eight weeks of use. Eight weeks of daily use also contributed to a significant improvement in the dryness/flaking, hyperpigmentation, and the overall appearance of sun-damaged skin. [1]
Salicylic acid has a long history of topical use, dating back to 2,000 years ago and over 100 years within clinical practice, to treat skin disorders. Topical salicylic acid treats acne by reducing swelling and redness while unplugging blocked skin pores to allow pimples to shrink. Its gentle exfoliating properties treat other skin conditions by softening and loosening dry, scaly, or thickened skin so that it falls off or can be removed easily. Salicylic acid is lipid-soluble, making it able to effectively penetrate the lipid barriers of the skin, including its pores. A number of studies have demonstrated the efficacy of 2% salicylic acid to reduce the number and severity of acne lesions with high tolerability. [2]
In addition to anti-inflammatory properties that reduce acne lesions, the lipid-soluble properties of salicylic acid reduce facial oil by removing intracellular lipids in the skin to further treat and prevent acne. Salicylic acid also contains antimicrobial properties to further combat acne caused by bacteria. A number of clinical studies have observed the efficacy of salicylic acid to safely reduce the the number and severity of acne lesions without affecting stratum corneum hydration, skin surface lipid, skin pH, and transepidermal water loss. This translates to reduced acne without the consequence of dry, flaky skin as skin moisture, appearance, and overall integrity are unaffected. Salicylic acid also works synergistically with niacinamide and yeast extract to to reduce hyperpigmentation in the skin for a balanced complexion.
Glycolic acid and lactic acid are well known alpha hydroxy acids which are widely used for improving signs of aging, dry skin, and an uneven skin tone. Topical lactic and glycolic acids have been recognized as superior alpha-hydroxy acids for improving skin hydration while reducing lines and wrinkles. Both acids reduce melanin pigments in the skin while increasing levels of collagen I and procollagen I. This results in a clearer skin complexion while rejuvenating photo-damaged and aged skin for a more youthful appearance.
Glycolic acid peel is the most common alpha-hydroxy acid peel, also known as fruit peel. Glycolic Acid 5% effectively reduces the sebum level in pores by 70%, as it clears away cellular debris within 24 hours, leaving skin blemish-free. Glycolic acid may also normalize keratinization and increase epidermal and dermal hyaluronic acid and collagen gene expression. This translates to improved skin integrity, including optimal moisture content.
Glycolic acid contains antioxidant and anti-inflammatory properties that can help treat erythema (i.e. redness and irritation of the skin) associated with acne vulgaris.
A well-recognized dermatological alpha-hydroxy acid, lactic acid provides beneficial modifications to the skin’s surface. Research has shown consistent application of lactic acid to increase skin firmness and thickness, improve skin smoothness, and reduce the appearance of lines and wrinkles. [13] Lactic acid has also been acknowledged for its high tolerability.
Lactic acid has shown to increase ceramide production in the outer layer skin (epidermal) cells. Ceramides form part of the skin’s natural barrier and contribute to skin integrity. Decreases in ceramide occurs with age and promotes dry skin, wrinkles and inflammation. Lactic acid treatment has shown to increase ceramide levels up to 48%. [15]
Beta-glucans are cell wall polysaccharides naturally derived from yeast (as in this formula), fungi (including mushrooms), seaweeds, and cereals. Naturally derived beta-glucans have shown to possess a number of health benefits, including benefits on the immune system and cholesterol levels. Beta-glucans have received attention in dermatological research for their antioxidant, anti-wrinkle, anti-ultraviolet light, wound healing, and moisturizing properties. Beta-glucan is aso acknowledged for its superior skin permeation absorption capacity.
Natural botanicals in this formula, including the extracts of cucumber, chamomile flower, aloe vera, and grapefruit contain noteworthy antioxidant, antibacterial, and aromatic benefits. Licorice and yeast (beta-glucans) brighten and even complexion with added softening and soothing benefits.
Grapefruit may inhibit elastase enzyme activity to prevent skin wrinkling and ageing. Cucumber contains bioactive compounds, including cucurbitacins and cucumerin A and B. Known for its antioxidant properties, cucumber may provide soothing, anti-irritating, and anti-inflammatory benefits on the skin.
Aloe barbadensis, also referred to as aloe vera, is recognized in research for its potent antibacterial properties. Topical aloe has shown to reduce the lesions, redness, and overall irritation associated with acne vulgaris. Aloe vera is also a natural humectant that effectively moisturizes skin to treat and prevent dry skin.
Allantoin is commonly used in moisturizers as a humectant offering effective hydration for dry skin. Literature has also demonstrated anti-irritant properties of allantoin.
Research has shown salicylic acid, in combination with lactic acid, resulted in significant reduction in fine lines, wrinkles, and skin dryness after eight weeks of use. Eight weeks of daily use also contributed to a significant improvement in dryness/flaking, hyperpigmentation, and the overall appearance of photodamaged skin. [1]
A number of studies have demonstrated the efficacy of 2% salicylic acid to reduce the number and severity of acne lesions with high tolerability. [2] One study found four weeks of face washing with a cleanser containing 2% salicylic acid resulted in significant in blackheads and acne. Improvements in skin appearance began after two weeks of use and progressively improved as the four week study continued. [3] Salicylic acid treatment has shown to safely and effectively reduce both inflammatory and non-inflammatory lesions without affecting stratum corneum hydration, skin surface lipid, skin pH, and transepidermal water loss (TEWL). [4] Increased TEWL impairs enzymatic functions required for normal desquamation of the skin and results in the visible appearance of dry, flaky skin. Therefore, research has observed acne-fighting properties of salicylic acid without negative effects on skin moisture, appearance, and overall integrity.
Research has shown that the anti-inflammatory properties of salicylic acid is most pronounced within a concentration of .5-5%, encompassing the ideal concentration included in this formula. [5] Salicylic acid has also shown to optimize the penetration of other topical agents applied simultaneously or included in the same formula. [6]
Salicylic acid helps control oily skin, facial shine, and acne by reducing sebum. One study found salicylic acid treatment to significantly reduce sebum secreted on the face. [7] Research has shown 2% salicylic acid concentrations to also reduce scarring that may be attributed by acne. [8] The anti-inflammatory properties of salicylic acid have been recognized for its protective effects on the skin, particularly against sun damage. [9]
Salicylic acid, in combination with yeast extract, has also shown to help even skin tone, decrease spot intensity, decrease spot size, and improve overall pigmentation. [10]
Long-term consistent topical application with glycolic acid has shown to increase hyaluronic acid and collagen gene expression in the skin. The results suggest that long-term use may also result in collagen deposition. [11] Glycolic acid contains antioxidant and anti-inflammatory properties that have shown to benefit sun-damaged skin, accelerating the healing rate while reducing erythema (i.e. redness and irritation of the skin). [12]
Research shows glycolic acid is effective at treating comedonal acne and improves inflammatory eruptions because of its growth inhibitory and antibacterial effects against Propionibacterium acnes. [13] The use of glycolic acid as a chemical peel has also shown to be a safe and effective treatment for melasma (light to deep brown pigmentation over cheeks, forehead, upper lip and nose). [14]
Long-term topical application of 5% lactic acid resulted in epidermal firmness and thickness, improved skin smoothness, and reduced appearance of lines and wrinkles. [15] Additional research has shown both lactic and glycolic acids to be the most effective acids compared to others (e.g. hydroxybutyric, malic acids). Both lactic and glycolic acids were also found to be less irritating than the other acids tested. Lactic acid and glycolic acid both produced similar improvements in skin hydration with reduced lines and wrinkles. Lactic acid was also recognized for the fewest consumer complaints compared to other acids tested. [16]
Lactic acid has also demonstrated the capacity to increase ceramides in keratinocytes with increases in stratum corneum ceramides up to 48%. Increases in ceramide levels optimizes lipid barrier and overall skin defenses and integrity. [17]
Additional research has demonstrated the efficacy and synergy of topical lactic acid and glycolic acid. Six weeks of daily topical application of lactic acid and glycolic acid resulted in reduced melanin pigments with increased levels of collagen I and procollagen I. The results of this study found glycolic and lactic to be superior alpha-hydroxy-acids for improving components in both the epidermal and dermal layers of the skin and rejuvenating photo-damaged skin. [18]
Clinical research and literature supports the benefits of beta-glucans as a protective and treating agent for wrinkles and UV radiation with antioxidant, wound-healing, and moisturizing properties. [19]
One study found grapefruit to inhibit the enzymatic activity of elastase, which degenerates dermal elastin. These results suggest that grapefruit possesses preventative and treatment properties against skin wrinkling and aging. [20]
Cucumber contains bioactive compounds, including cucurbitacins and cucumerin A and B. Known for its antioxidant properties, cucumber may provide soothing, anti-irritating, and anti-inflammatory benefits on the skin. [21]
Licorice is acknowledged as one of the safest pigment-lightening agents that may work by dispersing melanin and inhibiting tyrosinase activity in melanoma cells. Licorice contains active compounds, including liquiritin, isoliquiritigenin licuraside, isoliquiritin, and licochalcone A, and has been acknowledged for its antioxidant properties. [22][23]
Research has shown topical aloe vera application to significantly contribute to the reduction of lesions and erythema (i.e. redness and irritation of the skin) associated with acne vulgaris after 8 weeks of consistent use. [24] Additional research has shown aloe to contain natural humectant properties and improve skin moisture in dry skin. [25]
Allantoin is commonly used in moisturizers as a humectant, offering hydration for dry skin. In addition to promoting skin hydration, allantoin is also recognized for treating skin irritation. [26][27]
- 1. Katz BE, Lewis J, McHugh L, Pellegrino A, Popescu L. (2015). The Tolerability and Efficacy of a Three-product Anti-aging Treatment Regimen in Subjects with Moderate-to-severe Photodamage. The Journal of Clinical and Aesthetic Dermatology. 8(10):21-26.
- 2. Zander E, Weisman S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clin Ther. 14(2):247-53.
- 3. Shalita AR. (1989). Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in the treatment of acne vulgaris. Clin Ther. 11(2):264-7.
- 4. Lee HS, Kim IH. (2003). Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatol Surg. 29(12):1196-9; discussion 1199.
- 5. Arif T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology. 8:455-461.
- 6. Grimes PE. Salicylic acid. In: Tosti A, Grimes PE, Padova MP, editors. Color Atlas of Chemical Peels. 2nd ed. New York, NY, USA: Springer-Verlag; 2006.
- 7. Marczyk B, Mucha P, Budzisz E, Rotsztejn H. (2014). Comparative study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris. J Cosmet Dermatol. 13(1):15-21.
- 8. Danielson JR, Walter RJ. (2005). Case studies: Use of salicylic acid (Avosil) and hydrogel (Avogel) in limiting scar formation. J Burns Wounds. 28;4:e6.
- 9. Mammone T, Gan D, Goyarts E, Maes D. (2006). Salicylic acid protects the skin from UV damage. J Cosmet Sci. 57(2):203-4.
- 10. Draelos Z, Dahl A, Yatskayer M, Chen N, Krol Y, Oresajo C. (2013). Dyspigmentation, skin physiology, and a novel approach to skin lightening. J Cosmet Dermatol. 12(4):247-53.
- 11. Bernstein EF, Lee J, Brown DB, Yu R, Van Scott E. (2001). Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatol Surg. 27(5):429–433.
- 12. Perricone NV, DiNardo JC. (1996). Photoprotective and antiinflammatory effects of topical glycolic acid. Dermatol Surg. 22(5):435-7.
- 13. Takenaka Y, Hayashi N, Takeda M, Ashikaga S, Kawashima M. (2012). Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 350-4.
- 14. Sarkar R, Garg V, Bansal S, Sethi S, Gupta C. (2016). Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma. Dermatol Surg. 42(3):384-91.
- 15. Smith WP. (1996). Epidermal and dermal effects of topical lactic acid. J Am Acad Dermatol. 35(3 Pt 1):388-91.
- 16. Smith WP. (1996). Comparative effectiveness of alpha-hydroxy acids on skin properties. Int J Cosmet Sci. 18(2):75-83.
- 17. Rawlings AV, Davies A, Carlomusto M, Pillai S, Zhang K, Kosturko R, Verdejo P, Feinberg C, Nguyen L, Chandar P. (1996). Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res. 288(7):383-90.
- 18. Yamamoto Y, Uede K, Yonei N, Kishioka A, Ohtani T, Furukawa F. (2006). Effects of alpha-hydroxy acids on the human skin of Japanese subjects: the rationale for chemical peeling. J Dermatol. 33(1):16-22.
- 19. Du B, Bian Z, Xu B. (2014). Skin health promotion effects of natural beta-glucan derived from cereals and microorganisms: a review. Phytother Res. 28(2):159-66.
- 20. Mori M, Ikeda N, Kato Y, Minamino M, Watabe K. (2002). Inhibition of elastase activity by essential oils in vitro. J Cosmet Dermatol. 1(4):183-7.
- 21. Mukherjee PK, Nema NK, Maity N, Sarkar BK. (2013). Phytochemical and therapeutic potential of cucumber. Fitoterapia. 84:227-36.
- 22. Cronin H, Draelos ZD. (2010). Top 10 botanical ingredients in 2010 anti-aging creams. Journal of Cosmetic Dermatology. 9(3):218–225.
- 23. Binic I, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D. Skin Ageing: Natural Weapons and Strategies. Evidence-based Complementary and Alternative Medicine : eCAM. 2013;2013:827248.
- 24. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. (2014). Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat. 25(2):123-9.
- 25. Dal'Belo SE, Gaspar LR, Maia Campos PM. (2006). Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Skin Res Technol. 12(4):241-6.
- 26. Savić VLj, Nikolić VD, Arsić IA, Stanojević LP, Najman SJ, Stojanović S, Mladenović-Ranisavljević II. (2015). Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root. Phytother Res. 29(8):1117-22.
- 27. Rodan, K., Fields, K., Majewski, G., & Falla, T. (2016). Skincare Bootcamp: The Evolving Role of Skincare. Plastic and Reconstructive Surgery Global Open. 4(12 Suppl), e1152.
You May Also Want
Added to Your Cart

Anti-Aging System
Qty :
Flexible Spending and HSA Eligible
Services provided through INDUR are strictly self pay and INDUR will not submit a claim to your health insurance provider. However, you can submit the receipt for reimbursement to many Flexible Spending and Health Savings Accounts for reimbursement or you can submit a claim to your insurance company.